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A Simple Procedure to Assess Limit of Detection for Multisensor Systems.

ABSTRACT: Currently, there are no established procedures for limit of detection (LOD) evaluation in multisensor system studies, which complicates their correct comparison with other analytical techniques and hinders further development of the method. In this study we propose a simple and visually comprehensible approach for LOD estimation in multisensor analysis. The suggested approach is based on the assessment of evolution of mean relative error values in calibration series with growing analyte concentration. The LOD value is estimated as the concentration starting from which MRE values become stable from sample to sample. This intuitive procedure was successfully tested with a variety of real data from potentiometric multisensor systems.

SUBMITTER: Oleneva E

PROVIDER: S-EPMC6472210 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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A Simple Procedure to Assess Limit of Detection for Multisensor Systems.

Oleneva Ekaterina E Khaydukova Maria M Ashina Julia J Yaroshenko Irina I Jahatspanian Igor I Legin Andrey A Kirsanov Dmitry D

Sensors (Basel, Switzerland) 20190318 6

Currently, there are no established procedures for limit of detection (LOD) evaluation in multisensor system studies, which complicates their correct comparison with other analytical techniques and hinders further development of the method. In this study we propose a simple and visually comprehensible approach for LOD estimation in multisensor analysis. The suggested approach is based on the assessment of evolution of mean relative error values in calibration series with growing analyte concentr ...[more]

PMID: 30889940

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Project description:The development of electrochemical multisensor systems is driven by the need for fast, miniature, inexpensive, analytical devices, and advanced interdisciplinary based on both chemometric and (nano)material approaches. A multicomponent analysis of complex mixtures in environmental and technological monitoring, biological samples, and cell culture requires chip-based multisensor systems with high-stability sensors. In this paper, we describe the development, characterization, and applications of chip-based nanoelectrochemical sensor arrays prepared by the directed electrochemical nanowire assembly (DENA) of noble metals and metal alloys to analyze aqueous solutions. A synergic action of the electrode transducer function and electrocatalytic activity of the nanostructured surface toward analytes is achieved in the assembled metal nanowire (NW) sensors. Various sensor nanomaterials (Pd, Ni, Au, and their multicomponent compositions) can be electrochemically assembled on a single chip without employing multiple cycles of photolithography process to realize multi-analyte sensing applications as well as spatial resolution of sensor analysis by this single-chip multisensor system. For multi-analyte electrochemical sensing, individual amperometric signals of two or more nanowires can be acquired, making use of the specific electrocatalytic surface properties of the individual nanowire sensors of the array toward analytes. To demonstrate the application of a new electrochemical multisensor platform, Pd-Au, Pd-Ni, Pd, and Au NW electrode arrays on a single chip were employed for the non-enzymatic analysis of hydrogen peroxide, glucose, and ethanol. The analytes are determined at low absolute values of the detection potentials with linear concentration ranges of 1.0 × 10-6 - 1.0 × 10-3 M (H2O2), 1.5 × 10-7 - 2.0 × 10-3 M (glucose), and 0.7 × 10-3 - 3.0 × 10-2 M (ethanol), detection limits of 2 × 10-7 M (H2O2), 4 × 10-8 M (glucose), and 5.2 × 10-4 M (ethanol), and sensitivities of 18 ?A M-1 (H2O2), 178 ?A M-1 (glucose), and 28 ?A M-1 (ethanol), respectively. The sensors demonstrate a high level of stability due to the non-enzymatic detection mode. Based on the DENA-assembled nanowire electrodes of a compositional diversity, we propose a novel single-chip electrochemical multisensor platform, which is promising for acquiring complex analytical signals for advanced data processing with chemometric techniques aimed at the development of electronic tongue-type multisensor systems for flexible multi-analyte monitoring and healthcare applications.

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A Simple Procedure to Assess Limit of Detection for Multisensor Systems.

Publications

A Simple Procedure to Assess Limit of Detection for Multisensor Systems.

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