Ontology highlight
ABSTRACT:
SUBMITTER: Swaim CD
PROVIDER: S-EPMC6472260 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Swaim Caleb D CD Canadeo Larissa A LA Huibregtse Jon M JM
Methods in enzymology 20190201
ISG15 is a ubiquitin-like protein (Ubl) that is expressed in response to Type 1 Interferon (IFN-α/β) signaling. Remarkably, ISG15 has three distinct biochemical activities involved in innate immune responses to viral and/or microbial infections. The canonical function of ISG15 is as a posttranslational modifier, and protein ISGylation has been demonstrated to be antiviral. A second intracellular function, independent of conjugation activity, is attenuation of IFN-α/β signaling at the interferon ...[more]