Ontology highlight
ABSTRACT:
SUBMITTER: Patel SG
PROVIDER: S-EPMC6472342 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Patel Sanjay G SG Sayers Edward J EJ He Lin L Narayan Rohan R Williams Thomas L TL Mills Emily M EM Allemann Rudolf K RK Luk Louis Y P LYP Jones Arwyn T AT Tsai Yu-Hsuan YH
Scientific reports 20190418 1
Protein therapy holds great promise for treating a variety of diseases. To act on intracellular targets, therapeutic proteins must cross the plasma membrane. This has previously been achieved by covalent attachment to a variety of cell-penetrating peptides (CPPs). However, there is limited information on the relative performance of CPPs in delivering proteins to cells, specifically the cytosol and other intracellular locations. Here we use green fluorescent protein (GFP) as a model cargo to comp ...[more]