Ontology highlight
ABSTRACT:
SUBMITTER: Del Gaudio N
PROVIDER: S-EPMC6472371 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Del Gaudio Nunzio N Di Costanzo Antonella A Liu Ning Qing NQ Conte Lidio L Migliaccio Antimo A Vermeulen Michiel M Martens Joost H A JHA Stunnenberg Hendrik G HG Nebbioso Angela A Altucci Lucia L
Cell death & disease 20190418 5
Leukemia is characterized by genetic and epigenetic mutations resulting in selection of cancer cells, which are unable to differentiate. Although genetic alterations are difficult to target, the epigenome is intrinsically dynamic and readily offers new therapeutic strategies. Thus, identifying cancer-specific context-dependent targets and unraveling their biological function may open up new therapeutic perspectives. Here we identify bromodomain-containing protein 9 (BRD9) as a critical target re ...[more]