Ontology highlight
ABSTRACT:
SUBMITTER: Klingen TR
PROVIDER: S-EPMC6472403 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Klingen Thorsten R TR Loers Jens J Stanelle-Bertram Stephanie S Gabriel Gülsah G McHardy Alice C AC
Scientific reports 20190418 1
Human influenza A viruses elicit short-term respiratory infections with considerable mortality and morbidity. While H3N2 viruses circulate for more than 50 years, the recent introduction of pH1N1 viruses presents an excellent opportunity for a comparative analysis of the genome-wide evolutionary forces acting on both subtypes. Here, we inferred patches of sites relevant for adaptation, i.e. being under positive selection, on eleven viral protein structures, from all available data since 1968 and ...[more]