The Immunobiology of the Interleukin-12 Family: Room for Discovery.
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ABSTRACT:
SUBMITTER: Tait Wojno ED
PROVIDER: S-EPMC6472917 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
The Immunobiology of the Interleukin-12 Family: Room for Discovery.
Tait Wojno Elia D ED Hunter Christopher A CA Stumhofer Jason S JS
Immunity 20190401 4
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize shared receptors and cytokine subunits and influence the outcome of cancer, infection, and inflammatory diseases. Consequently, many facets of their biology are being therapeutically targeted. Here, we review the landmark discoveries in this field, the combinatorial biology inherent to this family, and ...[more]
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