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Biomedical applications of mRNA nanomedicine.

ABSTRACT: As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.

SUBMITTER: Xiong Q

PROVIDER: S-EPMC6472920 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Biomedical applications of mRNA nanomedicine.

Xiong Qingqing Q Lee Gha Young GY Ding Jianxun J Li Wenliang W Shi Jinjun J Shi Jinjun J

Nano research 20180727 10

As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhanc ...[more]

PMID: 31007865

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