Ontology highlight
ABSTRACT:
SUBMITTER: Kovina MV
PROVIDER: S-EPMC6473025 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kovina Marina V MV Karnaukhov Alexey V AV Krasheninnikov Mikhail E ME Kovin Artem L AL Gazheev Sarul T ST Sergievich Larisa A LA Karnaukhova Elena V EV Bogdanenko Elena V EV Balyasin Maxim V MV Khodarovich Yury M YM Dyuzheva Tatyana G TG Lyundup Alexey V AV
Frontiers in genetics 20190412
The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated animal was performed at the time when half of the population had already died. As a result, the maximum lifespan (MLS) increased by 28 ± 5%, and the survival time from the beginning o ...[more]