MicroRNA Dysregulation and Non-Muscle-Invasive Bladder Cancer Prognosis.

ABSTRACT: BACKGROUND:The high rate of non-muscle-invasive bladder cancer recurrence is a major challenge in patient management. miRNAs functionally regulate tumor cell proliferation and invasion, and have strong potential as biomarkers because they are robust to degradation. The objective of this project was to identify reproducible prognostic miRNAs in resected non-muscle-invasive bladder tumor tissue that are predictive of the recurrent tumor phenotype. METHODS:We utilized patients diagnosed with primary non-muscle-invasive bladder cancer in three independent cohorts for a biomarker discovery/validation approach. Baseline tumor tissue from patients with the clinically challenging, non-muscle-invasive primary low stage (Ta), high grade, and T1 tumors (tumors extending into the lamina propria) compr

SUBMITTER: Andrew AS 

PROVIDER: S-EPMC6473178 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature