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Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil.

ABSTRACT: In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations.

SUBMITTER: Parisi E

PROVIDER: S-EPMC6473331 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil.

Parisi Evelina E Garcia Ana M AM Marson Domenico D Posocco Paola P Marchesan Silvia S

Gels (Basel, Switzerland) 20190126 1

In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide ...[more]

PMID: 30691142

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