Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans.

ABSTRACT:

Objective

Aging is associated with impaired insulin sensitivity and increased prevalence of type 2 diabetes. However, it remains unclear whether aging-associated insulin resistance is due to increased adiposity or other age-related factors. To address this question, the impact of aging on insulin sensitivity was investigated independently of changes in body composition.

Methods

Cohorts of mice aged 4 to 8 months ("young") and 18 to 27 months ("aged") exhibiting similar body composition were characterized for glucose metabolism on chow and high-fat diets. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp analyses. The relationship between aging and insulin resistance in humans was investigated in 1,250 nondiabetic Mexican Americans who underwent hyperinsul

SUBMITTER: Ehrhardt N 

PROVIDER: S-EPMC6474357 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature