Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.
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ABSTRACT:
SUBMITTER: Povoleri GAM
PROVIDER: S-EPMC6474659 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Human retinoic acid-regulated CD161<sup>+</sup> regulatory T cells support wound repair in intestinal mucosa.
Povoleri Giovanni A M GAM Nova-Lamperti Estefania E Scottà Cristiano C Fanelli Giorgia G Chen Yun-Ching YC Becker Pablo D PD Boardman Dominic D Costantini Benedetta B Romano Marco M Pavlidis Polychronis P McGregor Reuben R Pantazi Eirini E Chauss Daniel D Sun Hong-Wei HW Shih Han-Yu HY Cousins David J DJ Cooper Nichola N Powell Nick N Kemper Claudia C Pirooznia Mehdi M Laurence Arian A Kordasti Shahram S Kazemian Majid M Lombardi Giovanna G Afzali Behdad B
Nature immunology 20181105 12
Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161<sup>+</sup> regulatory T (T<sub>reg</sub>) cells as a distinct, highly suppressive population of T<sub>reg</sub> cells that mediate wound healing. These T<sub>reg</sub> cells were enriched in intestinal lamina propria, particularly in Crohn's disease. CD161<sup>+</sup> T<sub>reg</sub> cells had an all-trans retinoic acid (ATRA)-regulated ...[more]
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