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Synthesis and Structure Revision of Symplocin A.

ABSTRACT: Symplocin A, a linear peptide possessing N-terminal N,N-dimethylisoleucine, statine, and valic acid residues, has been synthesized for the first time employing our previously established 'one-pot intramolecular tandem protocol'. Moreover, the stereochemistry of natural symplocin A was unambiguously revised through the confirmation by 1D NMR, 2D NMR, and HPLC comparisons with authentic natural product.

SUBMITTER: Shao LP

PROVIDER: S-EPMC6474688 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Synthesis and Structure Revision of Symplocin A.

Shao Lu-Ping LP Si Chang-Mei CM Mao Zhuo-Ya ZY Zhou Wen W Molinski Tadeusz F TF Wei Bang-Guo BG Lin Guo-Qiang GQ

Organic chemistry frontiers : an international journal of organic chemistry 20170209 6

Symplocin A, a linear peptide possessing N-terminal <i>N,N</i>-dimethylisoleucine, statine, and valic acid residues, has been synthesized for the first time employing our previously established '<i>one-pot intramolecular tandem protocol</i>'. Moreover, the stereochemistry of natural symplocin A was unambiguously revised through the confirmation by 1D NMR, 2D NMR, and HPLC comparisons with authentic natural product. ...[more]

PMID: 31007934

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