New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation.

ABSTRACT: Cardiac conduction disturbances are linked with arrhythmia development. The concept of safety factor (SF) has been derived to describe the robustness of conduction, but the usefulness of this metric has been constrained by several limitations. For example, due to the difficulty of measuring the necessary input variables, SF calculations have only been applied to synthetic data. Moreover, quantitative validation of SF is lacking; specifically, the practical meaning of particular SF values is unclear, aside from the fact that propagation failure (i.e., conduction block) is characterized by SF < 1. This study aims to resolve these limitations for our previously published SF formulation and explore its relationship to relevant electrophysiological properties of cardiac tissue. First, HL-1 card

SUBMITTER: Boyle PM 

PROVIDER: S-EPMC6474757 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature