Ontology highlight
ABSTRACT:
SUBMITTER: Boeynaems S
PROVIDER: S-EPMC6475405 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Boeynaems Steven S Holehouse Alex S AS Weinhardt Venera V Kovacs Denes D Van Lindt Joris J Larabell Carolyn C Van Den Bosch Ludo L Das Rhiju R Tompa Peter S PS Pappu Rohit V RV Gitler Aaron D AD
Proceedings of the National Academy of Sciences of the United States of America 20190329 16
Phase separation of multivalent protein and RNA molecules underlies the biogenesis of biomolecular condensates such as membraneless organelles. In vivo, these condensates encompass hundreds of distinct types of molecules that typically organize into multilayered structures supporting the differential partitioning of molecules into distinct regions with distinct material properties. The interplay between driven (active) versus spontaneous (passive) processes that are required for enabling the for ...[more]