Dataset Information

Protective Effect of the Total Triterpenes of Euscaphis konishii Hayata Pericarp on Bacillus Calmette-Guerin Plus Lipopolysaccharide-Induced Liver Injury.

ABSTRACT:

Background

Liver injury has been recognized as a primary cause of hepatic morbidity and mortality. Euscaphis konishii Hayata, also called Euscaphis fukienensis Hsu, is usually used as a detumescent and analgesic agent to improve liver function in South China, but its mechanism of action and chemical composition are unclear.

Objective

The main aim of the study was to investigate the constituent and potential hepatoprotective mechanism of the total triterpenes of E. konishii pericarp (TTEP).

Methods

The constituent of TTEP was analyzed by a series of silica gel column to get single compounds and then identified by NMR and MS. In vitro assays were conducted to test the free radical scavenging activity of TTEP. The BCG/LPS-induced immunological livery injury mice model was established to clarify the hepatoprotective effect of TTEP in vivo.

Results

8 pentacyclic triterpene acids were separated and identified by NMR and MS. TTEP treatment (50, 100, and 200 mg/Kg) improved the immune function of the BCG/LPS-infected mice, dose-dependently alleviated the BCG/LPS-induced inflammation and oxidative stress, and ameliorated the hepatocyte apoptosis in the liver tissue.

Conclusion

The pericarp of E. konishii may be further considered as a potent natural food for liver disease treatment.

SUBMITTER: Huang W

PROVIDER: S-EPMC6475556 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Protective Effect of the Total Triterpenes of <i>Euscaphis konishii</i> Hayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury.

Huang Wei W Ding Hui H Chen Lu-Yao LY Ni Lin L Ruan Yi-Fang YF Zou Xiao-Xing XX Ye Min M Zou Shuang-Quan SQ

Evidence-based complementary and alternative medicine : eCAM 20190404

<h4>Background</h4>Liver injury has been recognized as a primary cause of hepatic morbidity and mortality. <i>Euscaphis konishii</i> Hayata, also called <i>Euscaphis fukienensis</i> Hsu, is usually used as a detumescent and analgesic agent to improve liver function in South China, but its mechanism of action and chemical composition are unclear.<h4>Objective</h4>The main aim of the study was to investigate the constituent and potential hepatoprotective mechanism of the total triterpenes of <i>E. ...[more]

PMID: 31080480

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