Ontology highlight
ABSTRACT:
SUBMITTER: Zaslavsky K
PROVIDER: S-EPMC6475597 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature neuroscience 20190325 4
Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced pluripotent stem cells derived from neurotypic and ASD-affected donors. We developed sparse coculture for connectivity assays where SHANK2 and control neurons were differentially labeled and sparsely seeded together on a lawn of unlabeled control neurons. We observed increases in dendrite length, dendrite complexity, synapse number, and frequency of spo ...[more]