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The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection.


ABSTRACT: In this study we examined potential associations of HPV infection with the cervical microbiota. Cervical samples were collected from 87 HIV-seronegative reproductive-age Black South African women. Microbiota were characterized by Illumina sequencing of the V3-V4 hypervariable regions of the bacterial 16S rRNA gene. Thirty seven (42.5%) and 30 (34.5%) of the women had prevalent HPV and high-risk (HR)-HPV, respectively. Only 23 women (26.4%) had cervical microbiota dominated by a single Lactobacillus species (L. crispatus (2/87 (2.3%)), L. jensenii (2/87 (2.3%)), and L. iners (19/87 (21.8%)). The majority of the women (56/87 (64.4%)) had diverse cervical microbiota consisting of mainly bacterial vaginosis-associated bacteria. The remaining women (8/87 (9.2%)) had microbiota dominated by Aerococcus, Streptococcus, Chlamydia or Corynebacterium. Women with HR-HPV had significantly higher relative abundances of Aerococcaceae, Pseudomonadaceae and Bifidobacteriaceae compared to those with low-risk (LR)-HPV or no HPV-infection (LDA score >2.0, p?2.0, p??0.2). Further investigations of the bacterial taxa significantly enriched in HR-HPV-infected women are warranted.

SUBMITTER: Onywera H 

PROVIDER: S-EPMC6475661 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection.

Onywera Harris H   Williamson Anna-Lise AL   Mbulawa Zizipho Z A ZZA   Coetzee David D   Meiring Tracy L TL  

Papillomavirus research (Amsterdam, Netherlands) 20190413


In this study we examined potential associations of HPV infection with the cervical microbiota. Cervical samples were collected from 87 HIV-seronegative reproductive-age Black South African women. Microbiota were characterized by Illumina sequencing of the V3-V4 hypervariable regions of the bacterial 16S rRNA gene. Thirty seven (42.5%) and 30 (34.5%) of the women had prevalent HPV and high-risk (HR)-HPV, respectively. Only 23 women (26.4%) had cervical microbiota dominated by a single Lactobacil  ...[more]

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