Ontology highlight
ABSTRACT:
SUBMITTER: Watt KM
PROVIDER: S-EPMC6475694 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Watt Kevin M KM Hornik Christoph P CP Balevic Stephen J SJ Mundakel Gratias G Cotten C Michael CM Harper Barrie B Benjamin Daniel K DK Anand Ravinder R Laughon Matthew M Smith P Brian PB Cohen-Wolkowiez Michael M
British journal of clinical pharmacology 20190306 5
Ticarcillin-clavulanate covers a broad spectrum of pathogens that are common in premature infants. In infants <30 weeks gestational age, pharmacokinetic data to guide ticarcillin-clavulanate dosing are lacking. We enrolled 15 premature infants <30 weeks gestational age, determined pharmacokinetic parameters, and performed dosing simulations to determine optimal dosing for ticarcillin-clavulanate. The infants had a median (range) postnatal age (PNA) of 18 days (6-44 days) and gestational age of 2 ...[more]