Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC6476309 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Liu Wenjun W Wang Guanying G Palovcak Anna A Li Yan Y Hao Sophie S Liu Zhao-Jun ZJ Landgraf Ralf R Yuan Fenghua F Zhang Yanbin Y
DNA repair 20190227
FANCA is a key player in the canonical Fanconi anemia (FA) repair pathway. We have recently shown that FANCA also plays an important role in the single-strand annealing sub-pathway (SSA) of DNA double-strand break (DSB) repair by biochemically catalyzing single-strand annealing. Here, we report that a steroidal lactone withaferin A (WA) specifically impedes SSA repair by promoting FANCA downregulation at a sub-micromolar concentration range. We find that WA causes FANCA downregulation post-trans ...[more]