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ABSTRACT:
SUBMITTER: Eilertsen J
PROVIDER: S-EPMC6476317 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Eilertsen Justin J Stroberg Wylie W Schnell Santiago S
Mathematical biosciences 20180924
The determination of a substrate or enzyme activity by coupling one enzymatic reaction with another easily detectable (indicator) reaction is a common practice in the biochemical sciences. Usually, the kinetics of enzyme reactions is simplified with singular perturbation analysis to derive rate or time course expressions valid under the quasi-steady-state and reactant stationary state assumptions. In this paper, the dynamical behavior of coupled enzyme catalyzed reaction mechanisms is studied by ...[more]