Ontology highlight
ABSTRACT:
SUBMITTER: Pokusaeva VO
PROVIDER: S-EPMC6476524 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Pokusaeva Victoria O VO Usmanova Dinara R DR Putintseva Ekaterina V EV Espinar Lorena L Sarkisyan Karen S KS Mishin Alexander S AS Bogatyreva Natalya S NS Ivankov Dmitry N DN Akopyan Arseniy V AV Avvakumov Sergey Ya SY Povolotskaya Inna S IS Filion Guillaume J GJ Carey Lucas B LB Kondrashov Fyodor A FA
PLoS genetics 20190410 4
Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the evolutionarily-relevant segment of the fitness landscape of His3, a gene coding for an enzyme in the histidine synthesis pathway, focusing on combinations of amino acid states found at orthologous sites of extant species. Just 15% of amino acids found in yeast His3 orthologues were alw ...[more]