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Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.

ABSTRACT: This paper begins to build a theoretical framework that would enable the pharmaceutical industry to use network complexity measures as a way to identify drug targets. The variability of a betweenness measure for a network node is examined through different methods of network perturbation. Our results indicate a robustness of betweenness centrality in the identification of target genes.

SUBMITTER: Duron C

PROVIDER: S-EPMC6476710 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.

Durón Christina C Pan Yuan Y Gutmann David H DH Hardin Johanna J Radunskaya Ami A

Bulletin of mathematical biology 20181022 9

This paper begins to build a theoretical framework that would enable the pharmaceutical industry to use network complexity measures as a way to identify drug targets. The variability of a betweenness measure for a network node is examined through different methods of network perturbation. Our results indicate a robustness of betweenness centrality in the identification of target genes. ...[more]

PMID: 30350013

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