Ontology highlight
ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC6477155 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Immunity 20190326 4
Innate lymphoid cell (ILC) development proposes that ILC precursors (ILCPs) segregate along natural killer (NK) cell versus helper cell (ILC1, ILC2, ILC3) pathways, the latter depending on expression of Id2, Zbtb16, and Gata3. We have developed an Id2-reporter strain expressing red fluorescent protein (RFP) in the context of normal Id2 expression to re-examine ILCP phenotype and function. We show that bone-marrow ILCPs were heterogeneous and harbored extensive NK-cell potential in vivo and in vi ...[more]