Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC6477584 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zhao Zilong Z Li Fanjian F Guo Qi Q Zhou Yuan Y Miao Yuyang Y Li Ying Y Wang Zengguang Z Jiang Rongcai R Dong Jing-Fei JF Liu Xiao X Zhang Jianning J Zhang Yanjun Y
DNA and cell biology 20190206 4
Collagen is a major component of the subendothelial matrix and participates in bleeding arrest by activating and aggregating platelets at the site of vascular injury. The most common type I collagen exists in both soluble and fibrillar forms, but structural exchangeability between the two forms is currently unknown. Using atomic force microscopy, we show that type I collagen switches between soluble and fibrillar forms in a pH-dependent and ion-independent manner. Fibrillar collagen is rope like ...[more]