Dataset Information

Natural Course of Frailty Components in People Who Develop Frailty Syndrome: Evidence From Two Cohort Studies.

ABSTRACT:

Background

Frailty is an important geriatric syndrome, but little is known about its development in the years preceding onset of the syndrome. The aim of this study was to examine the progression of frailty and compare the trajectories of each frailty component prior to frailty onset.

Methods

Repeat data were from two cohort studies: the Longitudinal Aging Study Amsterdam (n = 1440) with a 15-year follow-up and the InCHIANTI Study (n = 998) with a 9-year follow-up. Participants were classified as frail if they had >3 frailty components (exhaustion, slowness, physical inactivity, weakness, and weight loss). Transitions between frailty components were examined with multistate modeling. Trajectories of frailty components were compared among persons who subsequently developed frailty to matched nonfrail persons by using mixed effects models.

Results

The probabilities were 0.43, 0.40, and 0.36 for transitioning from 0 to 1 frailty component, from 1 component to 2 components, and from 2 components to 3-5 components (the frail state). The transition probability from frail to death was 0.13. Exhaustion separated frail and nonfrail groups already 9 years prior to onset of frailty (pooled risk ratio [RR] = 1.53, 95% confidence interval [CI] 1.04-2.24). Slowness (RR = 1.94, 95% CI 1.44-2.61), low activity (RR = 1.59, 95% CI 1.19-2.13), and weakness (RR = 1.39, 95% CI 1.10-1.76) separated frail and nonfrail groups 6 years prior to onset of frailty. The fifth frailty component, weight loss, separated frail and nonfrail groups only at the onset of frailty (RR = 3.36, 95% CI 2.76-4.08).

Conclusions

Evidence from two cohort studies suggests that feelings of exhaustion tend to emerge early and weight loss near the onset of frailty syndrome.

SUBMITTER: Stenholm S

PROVIDER: S-EPMC6477647 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Natural Course of Frailty Components in People Who Develop Frailty Syndrome: Evidence From Two Cohort Studies.

Stenholm Sari S Ferrucci Luigi L Vahtera Jussi J Hoogendijk Emiel O EO Huisman Martijn M Pentti Jaana J Lindbohm Joni V JV Bandinelli Stefania S Guralnik Jack M JM Kivimäki Mika M

The journals of gerontology. Series A, Biological sciences and medical sciences 20190401 5

<h4>Background</h4>Frailty is an important geriatric syndrome, but little is known about its development in the years preceding onset of the syndrome. The aim of this study was to examine the progression of frailty and compare the trajectories of each frailty component prior to frailty onset.<h4>Methods</h4>Repeat data were from two cohort studies: the Longitudinal Aging Study Amsterdam (n = 1440) with a 15-year follow-up and the InCHIANTI Study (n = 998) with a 9-year follow-up. Participants we ...[more]

PMID: 30084927

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Dataset Information

Natural Course of Frailty Components in People Who Develop Frailty Syndrome: Evidence From Two Cohort Studies.

Background

Methods

Results

Conclusions

Publications

Natural Course of Frailty Components in People Who Develop Frailty Syndrome: Evidence From Two Cohort Studies.

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