Dataset Information

Predicting Behavior Problems in Korean Preschoolers: Interactions of the SLC6A4 Gene and Maternal Negative Affectivity.

ABSTRACT:

Objective

This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of SLC6A4 on behavior problems in children.

Methods

Study participants comprised 143 preschoolers and their mothers from South Korea. The Childhood Behavior Checklist and Emotionality, Activity, and Sociability adult scale were used to measure child behavior and maternal affectivity. DNA from saliva was genotyped to determine serotonin transporter polymorphism.

Results

MNA appeared to exert effects in externalizing (b =5.78, p＜0.001) and internalizing problems (b =6.09, p＜ 0.001). Interaction between SLCA4 polymorphism and MNA showed effects on externalizing (b =-7.62, p＜0.01) and internalizing problems (b =-9.77, p＜0.01). Children with two short alleles showed considerable differences in both externalizing and internalizing problems according to MNA; however, children with one short allele or none showed relatively few differences in behavior problems due to maternal affectivity.

Conclusion

The effect of SLC6A4 polymorphism on child behavior seemed to be moderated by MNA. In addition, the impact of MNA was found to vary based on a childs genetic risk. High MNA may trigger the risk allele while low MNA causes the risk allele to illicit less behavior problems. Children with two short variants of the SLC6A4 gene may benefit from intervention that modulates MNA.

SUBMITTER: Ha J

PROVIDER: S-EPMC6478087 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Predicting Behavior Problems in Korean Preschoolers: Interactions of the <i>SLC6A4</i> Gene and Maternal Negative Affectivity.

Ha Junghee J Jun Hey Jung HJ Shin Hyewon H Chung Ick Joong IJ Park Eunmie E Min Sung Kil SK Kim Eunjoo E

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 20190501 2

<h4>Objective</h4>This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of <i>SLC6A4</i> on behavior problems in children.<h4>Methods</h4>Study participants comprised 143 preschoolers and their mothers from South Korea. The Childhood Behavior Checklist and Emotionality, Activity, and Sociability adult scale were used to measure child behavior and maternal affectivity. DNA from saliva was genotyped to determine serotonin transport ...[more]

PMID: 30905120

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