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Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications.

ABSTRACT: Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action. It explains, say for example, why we cannot tickle ourselves. This review discusses how corollary discharge model is an essential neural integration mechanism central to the motor functioning of animal kingdom. In this article, research conducted in the field of corollary discharge has been reviewed to understand the neuroanatomical and neurophysiological basis of corollary discharge and gain insight into the biochemical basis of its dysfunction. This review article also explores the role of corollary discharge and its dysfunction in the presentation of symptoms of schizophrenia, discussing the findings from corollary discharge studies on schizophrenia population. Lastly, the link between schizophrenia psychopathology and corollary discharge dysfunction has been highlighted, and an attempt has been made to establish a case for correction of corollary discharge deficit in schizophrenia through neuromodulation.

SUBMITTER: Parlikar R

PROVIDER: S-EPMC6478093 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Eye movements as a probe of corollary discharge function in schizophrenia.

Project description:Nearly every movement made by every animal is accompanied by a corollary discharge, a signal sent from the motor to sensory regions of its brain. Corollary discharges are a crucial mechanism by which the brain monitors its own actions, and there is some evidence that they are impaired in people with schizophrenia. Here, I briefly review this evidence and suggest that eye movements are a particularly valuable tool for assessing the role of corollary discharges in schizophrenia.

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Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia.

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Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition.

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