A thalamocortical circuit for updating action-outcome associations.
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ABSTRACT:
SUBMITTER: Fresno V
PROVIDER: S-EPMC6478430 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
A thalamocortical circuit for updating action-outcome associations.
Fresno Virginie V Parkes Shauna L SL Faugère Angélique A Coutureau Etienne E Wolff Mathieu M
eLife 20190423
The ability to flexibly use knowledge is one cardinal feature of goal-directed behaviors. We recently showed that thalamocortical and corticothalamic pathways connecting the medial prefrontal cortex and the mediodorsal thalamus (MD) contribute to adaptive decision-making (Alcaraz et al., 2018). In this study, we examined the impact of disconnecting the MD from its other main cortical target, the orbitofrontal cortex (OFC) in a task assessing outcome devaluation after initial instrumental trainin ...[more]
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