Ontology highlight
ABSTRACT:
SUBMITTER: Jackson PEH
PROVIDER: S-EPMC6478720 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Jackson Patrick E H PEH Huang Jing J Sharma Monika M Rasmussen Sara K SK Hammarskjold Marie-Louise ML Rekosh David D
Scientific reports 20190423 1
The ability to overcome cellular restrictions that exist for the export and translation of mRNAs with retained introns is a requirement for the replication of retroviruses and also for the expression of many mRNA isoforms transcribed from cellular genes. In some cases, RNA structures have been identified in the mRNA that directly interact with cellular factors to promote the export and expression of isoforms with retained introns. In other cases, a viral protein is also required to act as an ada ...[more]