Ontology highlight
ABSTRACT:
SUBMITTER: Ortmayr K
PROVIDER: S-EPMC6478870 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ortmayr Karin K Dubuis Sébastien S Zampieri Mattia M
Nature communications 20190423 1
Transcriptional reprogramming of cellular metabolism is a hallmark of cancer. However, systematic approaches to study the role of transcriptional regulators (TRs) in mediating cancer metabolic rewiring are missing. Here, we chart a genome-scale map of TR-metabolite associations in human cells using a combined computational-experimental framework for large-scale metabolic profiling of adherent cell lines. By integrating intracellular metabolic profiles of 54 cancer cell lines with transcriptomic ...[more]