Ontology highlight
ABSTRACT:
SUBMITTER: Hortle E
PROVIDER: S-EPMC6478876 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20190423 1
Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berg ...[more]