Genome-wide association study of medication-use and associated disease in the UK Biobank.
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ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC6478889 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study of medication-use and associated disease in the UK Biobank.
Wu Yeda Y Byrne Enda M EM Zheng Zhili Z Kemper Kathryn E KE Yengo Loic L Mallett Andrew J AJ Yang Jian J Visscher Peter M PM Wray Naomi R NR
Nature communications 20190423 1
Genome-wide association studies (GWASs) of medication use may contribute to understanding of disease etiology, could generate new leads relevant for drug discovery and can be used to quantify future risk of medication taking. Here, we conduct GWASs of self-reported medication use from 23 medication categories in approximately 320,000 individuals from the UK Biobank. A total of 505 independent genetic loci that meet stringent criteria (P < 10<sup>-8</sup>/23) for statistical significance are iden ...[more]
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