Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC6478927 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zhang Jialiang J Bai Ruihong R Li Mei M Ye Huilin H Wu Chen C Wang Chengfeng C Li Shengping S Tan Liping L Mai Dongmei D Li Guolin G Pan Ling L Zheng Yanfen Y Su Jiachun J Ye Ying Y Fu Zhiqiang Z Zheng Shangyou S Zuo Zhixiang Z Liu Zexian Z Zhao Qi Q Che Xu X Xie Dan D Jia Weihua W Zeng Mu-Sheng MS Tan Wen W Chen Rufu R Xu Rui-Hua RH Zheng Jian J Lin Dongxin D
Nature communications 20190423 1
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification is an important mechanism in miRNA processing and maturation, but the role of its aberrant regulation in human diseases remained unclear. Here, we demonstrate that oncogenic primary microRNA-25 (miR-25) in pancreatic duct epithelial cells can be excessively maturated by cigarette smoke condensate (CSC) via enhanced m<sup>6</sup>A modification that is mediated by NF-κB associated protein (NKAP). This modification is catalyzed by overexpr ...[more]