Ontology highlight
ABSTRACT:
SUBMITTER: Tokumaru Y
PROVIDER: S-EPMC6479539 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Tokumaru Yoshihisa Y Tajirika Toshihiro T Sugito Nobuhiko N Kuranaga Yuki Y Shinohara Haruka H Tsujino Takuya T Matsuhashi Nobuhisa N Futamura Manabu M Akao Yukihiro Y Yoshida Kazuhiro K
International journal of molecular sciences 20190405 7
Gastric cancer (GC) is one of the most common cancers worldwide. In the clinical setting, the identification of HER2 overexpression in GC was a significant finding, as trastuzumab, an anti-HER2 drug, provides a survival advantage to HER2-positive GC patients. In HER2-postive GC, the dysregulation of PI3K/AKT and MAPK/ERK signaling pathways has been reported, and inhibition of these pathways is an important therapeutic strategy. MiR-143 is known to act as a tumor suppressor in several cancers, su ...[more]