Dataset Information

Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling.

ABSTRACT: Mineralocorticoid receptor (MR)-mediated signaling in the brain has been suggested as a protective factor in the development of psychopathology, in particular mood disorders. We recently identified genomic loci at which either MR or the closely related glucocorticoid receptor (GR) binds selectively, and found members of the NeuroD transcription factor family to be specifically associated with MR-bound DNA in the rat hippocampus. We show here using forebrain-specific MR knockout mice that GR binding to MR/GR joint target loci is not affected in any major way in the absence of MR. Neurod2 binding was also independent of MR binding. Moreover, functional comparison with MyoD family members indicates that it is the chromatin remodeling aspect of NeuroD, rather than its direct stimulation of transcription, that is responsible for potentiation of MR-mediated transcription. These findings suggest that NeuroD acts in a permissive way to enhance MR-mediated transcription, and they argue against competition for DNA binding as a mechanism of MR- over GR-specific binding.

SUBMITTER: van Weert LTCM

PROVIDER: S-EPMC6479562 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling.

van Weert Lisa T C M LTCM Buurstede Jacobus C JC Sips Hetty C M HCM Mol Isabel M IM Puri Tanvi T Damsteegt Ruth R Roozendaal Benno B Sarabdjitsingh R Angela RA Meijer Onno C OC

International journal of molecular sciences 20190329 7

Mineralocorticoid receptor (MR)-mediated signaling in the brain has been suggested as a protective factor in the development of psychopathology, in particular mood disorders. We recently identified genomic loci at which either MR or the closely related glucocorticoid receptor (GR) binds selectively, and found members of the NeuroD transcription factor family to be specifically associated with MR-bound DNA in the rat hippocampus. We show here using forebrain-specific MR knockout mice that GR bind ...[more]

PMID: 30934833

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Dataset Information

Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling.

Publications

Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling.

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