Ontology highlight
ABSTRACT:
SUBMITTER: Haidar S
PROVIDER: S-EPMC6479664 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Haidar Samer S Aichele Dagmar D Birus Robin R Hielscher Janine J Laitinen Tuomo T Poso Antti A Jose Joachim J
Molecules (Basel, Switzerland) 20190408 7
Protein kinase CK2 is an emerging target for therapeutic intervention in human diseases, particularly in cancer. Inhibitors of this enzyme are currently in clinical trials, indicating the druggability of human CK2. By virtual screening of the ZINC database, we found that the natural compound bikaverin can fit well in the ATP binding site of the target enzyme CK2. By further in vitro evaluation using CK2 holoenzyme, bikaverin turned to be a potent inhibitor with an IC<sub>50</sub> value of 1.24 µ ...[more]