Liver-specific ROR? deletion does not affect the metabolic susceptibility to western style diet feeding.

ABSTRACT: OBJECTIVES:The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (ROR?) as an important nuclear receptor involved in several biological processes. ROR? full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic ROR? by generating mice with liver-specific ROR? deletion to elucidate the role of this nuclear receptor on host metabolism. METHODS:8 week-old mice with liver-specific ROR? deletion and littermate controls were fed either chow or western-style diets (40% fat, 40% carbohydrate) for 12 weeks. Metabolic phenotyping was performed at the end of the dietary intervention. RESULTS:Here, we show that hepatic ROR? deletion does not affect the metabolic susceptibility to either chow or western-style diet in terms of glucose metabolism and adiposity. CONCLUSIONS:Our data indicate that liver deletion of ROR? does not have a pivotal role in the regulation of hepatic glucose and lipid metabolism on chow or western-style diet.

SUBMITTER: Molinaro A 

PROVIDER: S-EPMC6479759 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature