Investigating the Influence of Steric Hindrance on Selective Anion Transport.
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ABSTRACT:
SUBMITTER: Jowett LA
PROVIDER: S-EPMC6480120 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Investigating the Influence of Steric Hindrance on Selective Anion Transport.
Jowett Laura A LA Ricci Angela A Wu Xin X Howe Ethan N W ENW Gale Philip A PA
Molecules (Basel, Switzerland) 20190402 7
A series of symmetrical and unsymmetrical alkyl tren based tris-thiourea anion transporters were synthesised and their anion binding and transport properties studied. Overall, increasing the steric bulk of the substituents resulted in improved chloride binding and transport abilities. Including a macrocycle in the scaffold enhanced the selectivity of chloride transport in the presence of fatty acids, by reducing the undesired H⁺ flux facilitated by fatty acid flip-flop. This study demonstrates t ...[more]
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