Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain.
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ABSTRACT: Background
Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent stress (CIS) on nociceptive behaviors and brain-derived nerve growth factor (BDNF) system in the prefrontal cortex (PFC) and hypothalamus of rats with and without thermal injury.Results
Unstressed rats showed transient mechanical allodynia during stress exposure. Stressed rats with thermal injury displayed persistent exacerbated mechanical allodynia (P?ConclusionThese results indicate that BDNF-TrkB signaling in PFC and hypothalamus contributes to CIS-induced exacerbated mechanical allodynia in thermal injury state.
SUBMITTER: Sosanya NM
PROVIDER: S-EPMC6480655 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain.
Sosanya Natasha M NM Garza Thomas H TH Stacey Winfred W Crimmins Stephen L SL Christy Robert J RJ Cheppudira Bopaiah P BP
BMC neuroscience 20190424 1
<h4>Background</h4>Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent stress (CIS) on nociceptive behaviors and brain-derived nerve growth factor (BDNF) system in the prefrontal cortex (PFC) and hypothalamus of rats with and without thermal injury.<h4>Results</h4>Unstressed rats showed transient mechanical allodynia during stress exposure. ...[more]
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