Targeting CLL-1 for acute myeloid leukemia therapy.
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ABSTRACT:
SUBMITTER: Ma H
PROVIDER: S-EPMC6480870 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Targeting CLL-1 for acute myeloid leukemia therapy.
Ma Hongbing H Padmanabhan Iyer Swaminathan IS Parmar Simrit S Gong Yuping Y
Journal of hematology & oncology 20190424 1
Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing number of targets such as CD33, CD123, CLL-1, CD47, CD70, and TIM3, have been developed for immunotherapy of AML. Among them, CLL-1 has attracted the researchers' attention due to its high expression in AML while being absent in normal hematopoietic stem cell. Acc ...[more]
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