Ontology highlight
ABSTRACT:
SUBMITTER: Cooke RE
PROVIDER: S-EPMC6481018 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Journal of oncology 20190410
Multiple myeloma (MM) is usually diagnosed in older adults at the time of immunosenescence, a collection of age-related changes in the immune system that contribute to increased susceptibility to infection and cancer. The MM tumor microenvironment and cumulative chemotherapies also add to defects in immunity over the course of disease. In this review we discuss how mouse models have furthered our understanding of the immune defects caused by MM and enabled immunotherapeutics to progress to clini ...[more]