Dataset Information

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

ABSTRACT:

Objective

To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.

Design

Individual participant data meta-analysis.

Setting

Cohorts from 40 countries with data collected between 1970 and 2017.

Participants

Adults in 39 general population cohorts (n=5?459?014), of which 21 (n=594?496) had data on waist circumference; six cohorts with high cardiovascular risk (n=84?417); and 18 cohorts with chronic kidney disease (n=91?607).

Main outcome measures

GFR decline (estimated GFR decline ?40%, initiation of kidney replacement therapy or estimated GFR <10 mL/min/1.73 m²) and all cause mortality.

Results

Over a mean follow-up of eight years, 246?607 (5.6%) individuals in the general population cohorts had GFR decline (18?118 (0.4%) end stage kidney disease events) and 782?329 (14.7%) died. Adjusting for age, sex, race, and current smoking, the hazard ratios for GFR decline comparing body mass indices 30, 35, and 40 with body mass index 25 were 1.18 (95% confidence interval 1.09 to 1.27), 1.69 (1.51 to 1.89), and 2.02 (1.80 to 2.27), respectively. Results were similar in all subgroups of estimated GFR. Associations weakened after adjustment for additional comorbidities, with respective hazard ratios of 1.03 (0.95 to 1.11), 1.28 (1.14 to 1.44), and 1.46 (1.28 to 1.67). The association between body mass index and death was J shaped, with the lowest risk at body mass index of 25. In the cohorts with high cardiovascular risk and chronic kidney disease (mean follow-up of six and four years, respectively), risk associations between higher body mass index and GFR decline were weaker than in the general population, and the association between body mass index and death was also J shaped, with the lowest risk between body mass index 25 and 30. In all cohort types, associations between higher waist circumference and higher waist-to-height ratio with GFR decline were similar to that of body mass index; however, increased risk of death was not associated with lower waist circumference or waist-to-height ratio, as was seen with body mass index.

Conclusions

Elevated body mass index, waist circumference, and waist-to-height ratio are independent risk factors for GFR decline and death in individuals who have normal or reduced levels of estimated GFR.

SUBMITTER: Chang AR

PROVIDER: S-EPMC6481269 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

Chang Alex R AR Grams Morgan E ME Ballew Shoshana H SH Bilo Henk H Correa Adolfo A Evans Marie M Gutierrez Orlando M OM Hosseinpanah Farhad F Iseki Kunitoshi K Kenealy Timothy T Klein Barbara B Kronenberg Florian F Lee Brian J BJ Li Yuanying Y Miura Katsuyuki K Navaneethan Sankar D SD Roderick Paul J PJ Valdivielso Jose M JM Visseren Frank L J FLJ Zhang Luxia L Gansevoort Ron T RT Hallan Stein I SI Levey Andrew S AS Matsushita Kunihiro K Shalev Varda V Woodward Mark M

BMJ (Clinical research ed.) 20190110

<h4>Objective</h4>To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.<h4>Design</h4>Individual participant data meta-analysis.<h4>Setting</h4>Cohorts from 40 countries with data collected between 1970 and 2017.<h4>Participants</h4>Adults in 39 general population cohorts (n=5 459 014), of which 21 (n=594 496) had data on waist circumference; six coho ...[more]

PMID: 30630856

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Dataset Information

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

Objective

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

Similar Datasets

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