Metabolic Determinants of Weight Gain in Humans.

ABSTRACT: One of the fundamental challenges in obesity research is to identify subjects prone to weight gain so that obesity and its comorbidities can be promptly prevented or treated. The principles of thermodynamics as applied to human body energetics demonstrate that susceptibility to weight gain varies among individuals as a result of interindividual differences in energy expenditure and energy intake, two factors that counterbalance one another and determine daily energy balance and, ultimately, body weight change. This review focuses on the variability among individuals in human metabolism that determines weight change. Conflicting results have been reported about the role of interindividual differences in energy metabolism during energy balance in relation to future weight change. However, re

SUBMITTER: Piaggi P 

PROVIDER: S-EPMC6481299 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature