Ontology highlight
ABSTRACT:
SUBMITTER: Hill SE
PROVIDER: S-EPMC6482087 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Hill Sarah E SE Kauffman Karlina J KJ Krout Mia M Richmond Janet E JE Melia Thomas J TJ Colón-Ramos Daniel A DA
Developmental cell 20190314 2
In neurons, defects in autophagosome clearance have been associated with neurodegenerative disease. Yet, the mechanisms that coordinate trafficking and clearance of synaptic autophagosomes are poorly understood. Here, we use genetic screens and in vivo imaging in single neurons of C. elegans to identify mechanisms necessary for clearance of synaptic autophagosomes. We observed that autophagy at the synapse can be modulated in vivo by the state of neuronal activity, that autophagosomes undergo UN ...[more]