Ontology highlight
ABSTRACT:
SUBMITTER: Cunha JE
PROVIDER: S-EPMC6482306 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cunha Jonathan Emanuel JE Barbosa Germanna Medeiros GM Castro Paula Aiello Tomé de Souza PATS Luiz Beatriz Leite Ferreira BLF Silva Andreza Cristine Arcari ACA Russo Thiago Luiz TL Vasilceac Fernando Augusto FA Cunha Thiago Mattar TM Cunha Fernando Queiróz FQ Salvini Tania Fátima TF
Scientific reports 20190424 1
Knee osteoarthritis (KOA) is associated with muscle weakness, but it is unclear which structures are involved in the muscle changes. This study assessed morphological alterations and the expression of genes and proteins linked to muscular atrophy and neuromuscular junctions (NMJs) in KOA, induced by anterior cruciate ligament transection (ACLT) in rats. Two groups of rats were assessed: control (without intervention) and KOA (ACLT surgery in the right knee). After 8 weeks, quadriceps, tibialis a ...[more]