Ontology highlight
ABSTRACT:
SUBMITTER: Insuela DBR
PROVIDER: S-EPMC6482309 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Insuela Daniella B R DBR Azevedo Carolina T CT Coutinho Diego S DS Magalhães Nathalia S NS Ferrero Maximiliano R MR Ferreira Tatiana Paula T TPT Cascabulho Cynthia M CM Henriques-Pons Andrea A Olsen Priscilla C PC Diaz Bruno L BL Silva Patricia M R PMR Cordeiro Renato S B RSB Martins Marco A MA Carvalho Vinicius F VF
Scientific reports 20190424 1
Glucagon has been shown to be beneficial as a treatment for bronchospasm in asthmatics. Here, we investigate if glucagon would prevent airway hyperreactivity (AHR), lung inflammation, and remodeling in a murine model of asthma. Glucagon (10 and 100 µg/Kg, i.n.) significantly prevented AHR and eosinophilia in BAL and peribronchiolar region induced by ovalbumin (OVA) challenge, while only the dose of 100 µg/Kg of glucagon inhibited subepithelial fibrosis and T lymphocytes accumulation in BAL and l ...[more]