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Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel.

ABSTRACT: Based on the scaffold of astemizole, three novel turn-on fluorescent probes (N1-N3) for human ether-a-go-go-related gene (hERG) potassium channel were developed herein. These probes have reasonable fluorescence properties, acceptable cell toxicity, and potent inhibitory activity, all of which contribute to cell imaging at the nanomolar level. Overall, these probes have the potential for setting up a screening system for hERG channels.

SUBMITTER: Zhang X

PROVIDER: S-EPMC6482408 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel.

Zhang Xiaomeng X Liu Tingting T Wang Beilei B Gao Yuqi Y Liu Pan P Li Minyong M Du Lupei L

MedChemComm 20190226 4

Based on the scaffold of astemizole, three novel turn-on fluorescent probes (N1-N3) for human ether-a-go-go-related gene (hERG) potassium channel were developed herein. These probes have reasonable fluorescence properties, acceptable cell toxicity, and potent inhibitory activity, all of which contribute to cell imaging at the nanomolar level. Overall, these probes have the potential for setting up a screening system for hERG channels. ...[more]

PMID: 31057730

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