Ontology highlight
ABSTRACT:
SUBMITTER: Kildahl-Andersen G
PROVIDER: S-EPMC6482411 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
MedChemComm 20190308 4
The syntheses of metallo-β-lactamase inhibitors comprising chelating moieties, with varying zinc affinities, and peptides partly inspired from bacterial peptide sequences, have been undertaken. The zinc chelator strength was varied using the following chelators, arranged in order of ascending binding affinity: dipicolylamine (DPA, tridentate), dipicolyl-1,2,3-triazolylmethylamine (DPTA, tetradentate) dipicolyl ethylenediamine (DPED, tetradentate) and trispicolyl ethylenediamine (TPED, pentadenta ...[more]