Ontology highlight
ABSTRACT:
SUBMITTER: Kildahl-Andersen G
PROVIDER: S-EPMC6482411 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Kildahl-Andersen Geir G Schnaars Christian C Prandina Anthony A Radix Sylvie S Le Borgne Marc M Jordheim Lars Petter LP Gjøen Tor T Andresen Adriana Magalhães Santos AMS Lauksund Silje S Fröhlich Christopher C Samuelsen Ørjan Ø Rongved Pål P Åstrand Ove Alexander Høgmoen OAH
MedChemComm 20190308 4
The syntheses of metallo-β-lactamase inhibitors comprising chelating moieties, with varying zinc affinities, and peptides partly inspired from bacterial peptide sequences, have been undertaken. The zinc chelator strength was varied using the following chelators, arranged in order of ascending binding affinity: dipicolylamine (DPA, tridentate), dipicolyl-1,2,3-triazolylmethylamine (DPTA, tetradentate) dipicolyl ethylenediamine (DPED, tetradentate) and trispicolyl ethylenediamine (TPED, pentadenta ...[more]