Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6482957 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Zhang Yi Y Xue Yongming Y Shi Jiejun J Ahn JaeWoo J Mi Wenyi W Ali Muzaffar M Wang Xiaolu X Klein Brianna J BJ Wen Hong H Li Wei W Shi Xiaobing X Kutateladze Tatiana G TG
Nature structural & molecular biology 20180827 9
Human p300 is a transcriptional co-activator and a major acetyltransferase that acetylates histones and other proteins facilitating gene transcription. The activity of p300 relies on the fine-tuned interactome that involves a dozen p300 domains and hundreds of binding partners and links p300 to a wide range of vital signaling events. Here, we report a novel function of the ZZ-type zinc finger (ZZ) of p300 as a reader of histone H3. We show that the ZZ domain and acetyllysine-recognizing bromodom ...[more]